Gallbladder cancer pandemiology
Gallbladder cancer is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developing countries. Late analisis and deprived prognosis are major problems for treatment of gallbladder carcinoma. The dramatic associations of this orphan cancer with various genetic and environmental factors are responsible for its poorly defined pathogenesis. An understanding to the relationship between pandemiology, molecular genetics and pathogenesis of gallbladder cancer can add new insights to its undetermined pathophysiology. Present ulasan article provides a recent update regarding pandemiology, pathogenesis, and molecular genetics of gallbladder cancer. We systematically ulasaned published literature on gallbladder cancer from online mesin pencari PubMed (http://www.ncbi.nlm.nih.gov/pubmed). Various kata kunci (keyword) used for retrieval of articles were Gallbladder, cancer Pandemiology, molecular genetics and bullion operators like AND, OR, NOT. Cross references were manually searched from various online search engines (http://www.ncbi.nlm.nih.gov/pubmed,https://scholar.google.co.in/, http://www.medline.com/home.jsp). Most of the articles published from 1982 to 2015 in peer ulasaned journals have been included in this ulasan. Cara Bermain Judi Sabung Ayam Online
Kata kunci (keyword): Gallbladder cancer, Pandemiology, Molecular genetics, Pathogenesis
Core panduan: The Gallbladder cancer is a fatal malignancy which displays considerable differences in certain ethnicities and geographic regions. Indo-Gangetic plains of India, Mapuche Indians in Chile and South America are most affected regions with this cancer. Because of this cancer is largely unstudied as compare to other cancers Present ulasan provides a comprehensive summery of the studies conducted regarding its Pandemiology, Pathogenesis and molecular genetics. This will be helpful for the researchers to understand the current scenario of research work and how much success we have gained till now. Based on which future research work can be planned in appropriate directions.
Gallbladder cancer (GBC) is a rare biliary tract malignancy in most western countries, but is much widespread in some other regions of the world. Moreover, this carcinoma is infrequent in developed countries but more common in some developing countries, characterized by its lack of symptoms at initial stage leading to difficulties in treatment.
The extensive variation in geography, ethnicity, and cultural differences in the incidence of gallbladder cancer suggests the role of key genetic and environmental factors associated with the development and progression of the disease[1,2]. The lack of a serosal layer of gallbladder adjacent to the liver thus enabling hepatic invasion and metastatic progression is one of the major cause of its miserable prognosis[3]. The present ulasan provides a recent update of studies regarding pandemiology, pathogenesis and molecular genetics of gallbladder cancer as available in literature.
